Product Details
| Cat # +Size | 3580-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | IRAK-4 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide mapping to the C-terminus of human IRAK-4 |
| Accession # | Q9NWZ3 |
| Gene ID | 51135 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | Western blot |
| Application & Usage | Western blotting (2-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 50 kDa human IRAK-4. Reactivity of the antibody to other species has not been tested. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The IRAK family members play an important role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK-4 is a novel member in the IRAK family. Over expression of IRAK-4 activates NFkB and MAPK pathways. Animas and human lacking IRAK-4 are impaired in their responses to viral and bacterial challenges.
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