Product Details
| abID | ab142079 |
|---|---|
| Cat # +Size | 1663-1 |
| Size | 1 mg |
| Alternate Name | 2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide |
| Appearance | Orange solid |
| CAS # | 331001-62-8 |
| Molecular Formula | C₂₁H₂₂N₄O₂ |
| Molecular Weight | 362.42 |
| Purity | ≥95% by HPLC |
| Solubility | DMSO |
| SMILES | CC(=O)C1=CC=C(C=C1)N=NC(C2C3=CC=CC=C3CC(N2)(C)C)C(=O)N |
| InChi | InChI=1S/C21H24N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17-7-5-4-6-15(17)12-21(2,3)23-18/h4-11,18-19,23H,12H2,1-3H3,(H2,22,27) |
| InChi Key | WQFHCZGUBRVAAW-UHFFFAOYSA-N |
| PubChem CID | 11152734 |
| MDL Number | MFCD00354369 |
| Handling | Protect from air and light |
| Storage Conditions | 4°C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents β-catenin from switching coactivator usage from CBP to p300. The increase in β-cateinin/CBP mediated transcription at the expense of β-cateinin/p300-mediated transcription helps to maintain the murine stem cell pluripotency.
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