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IPI-145

A potent PI3K-delta/gamma isoform inhibitor
Catalog #: 2445
SKU-Size Size Price Qty
2445-5 5 mg
$125.00
2445-25 25 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name (S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one
Appearance White solid
CAS # 1201438-56-3
Molecular Formula C₂₂H₁₇ClN₆O
Molecular Weight 416.86
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
InChi InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1
InChi Key SJVQHLPISAIATJ-ZDUSSCGKSA-N
PubChem CID 50905713
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IPI-145 is a potent inhibitor of phosphoinositide-3-kinase (PI3K)-d and PI3K-γ isoforms with potential immunomodulating and antineoplastic activities. IPI-145 prevents the activation of the PI3Kd/γ-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3Kd/γ-expressing tumor cells.


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