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IPA-3

A PAK1 inhibitor
Catalog #: 2647
SKU-Size Size Price Qty
2647-5 5 mg
$95.00
2647-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 1,​1'-​dithiobis-​2-​naphthalenol
Appearance Yellow solid
CAS # 42521-82-4
Molecular Formula C₂₀H₁₄O₂S₂
Molecular Weight 350.45
Purity ≥95%
Solubility DMSO (~ 25 mg/ml)
SMILES C1=CC=C2C(=C1)C=CC(=C2SSC3=C(C=CC4=CC=CC=C43)O)O
InChi InChI=1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChi Key RFAXLXKIAKIUDT-UHFFFAOYSA-N
PubChem CID 521106
MDL Number MFCD00388917
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IPA-3 is a cell-permeable allosteric inhibitor of PAK1 (tha p21-activated kinase 1) that is non-competitive with respect to ATP binding (IC₅₀ = 2.5 µM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42. Potential anti-tumor agent.


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