Product Details
| Alternate Name | 1,1'-dithiobis-2-naphthalenol |
|---|---|
| Appearance | Yellow solid |
| CAS # | 42521-82-4 |
| Molecular Formula | C₂₀H₁₄O₂S₂ |
| Molecular Weight | 350.45 |
| Purity | ≥95% |
| Solubility | DMSO (~ 25 mg/ml) |
| SMILES | C1=CC=C2C(=C1)C=CC(=C2SSC3=C(C=CC4=CC=CC=C43)O)O |
| InChi | InChI=1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H |
| InChi Key | RFAXLXKIAKIUDT-UHFFFAOYSA-N |
| PubChem CID | 521106 |
| MDL Number | MFCD00388917 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
IPA-3 is a cell-permeable allosteric inhibitor of PAK1 (tha p21-activated kinase 1) that is non-competitive with respect to ATP binding (IC₅₀ = 2.5 µM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42. Potential anti-tumor agent.
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