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IOX3 (FG-2216)

An orally active PHD2 inhibitor
Catalog #: B2739
SKU-Size Size Price Qty
B2739-5 5 mg
$115.00
B2739-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-glycine
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 223387-75-5
Molecular Formula C₁₂H₉ClN₂O₄
Molecular Weight 280.7
Purity ≥98%
Solubility ~20 mg/ml DMSO
SMILES OC1=C(C(NCC(O)=O)=O)N=C(Cl)C2=CC=CC=C21
InChi InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)
InChi Key OUQVKRKGTAUJQA-UHFFFAOYSA-N
PubChem CID 6914666
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IOX3 (FG-2216) is a potent, orally bioavailable HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.9 µM for PDH2 enzyme. It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro.


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