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IOX2

A selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2)
Catalog #: 9451
SKU-Size Size Price Qty
9451-5 5 mg
$95.00
9451-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Appearance White solid
CAS # 931398-72-0
Molecular Formula C₁₉H₁₆N₂O₅
Molecular Weight 352.34
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
InChi InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
InChi Key CAOSCCRYLYQBES-UHFFFAOYSA-N
PubChem CID 54685215
MDL Number MFCD22580424
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IOX-2 is a potent, cell-permeable and selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC₅₀ = 21 nM). It displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.


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