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IOX1

Histone demethylase JMJD inhibitor
Catalog #: 2266
SKU-Size Size Price Qty
2266-5 5 mg
$75.00
2266-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 8-Hydroxy-5-quinolinecarboxylic acid; 8-Hydroxy-5-quinolinecarboxylic acid
Peptide Sequence No
Appearance Yellow solid
CAS # 5852-78-8
Molecular Formula C₁₀H₇NO₃
Molecular Weight 189.17
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
InChi InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChi Key JGRPKOGHYBAVMW-UHFFFAOYSA-N
PubChem CID 459617
MDL Number MFCD18417145
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A histone demethylase (HDM) JMJD nhibitor. Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC₅₀s = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 µM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively. A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling.


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