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INS, 25-110 aa, His-tag, Human Recombinant

Essential hormone for maintaining metabolic homeostasis
Catalog #: P1302

In stock

SKU-Size Size Price Qty
P1302-5 5 µg
$165.00
P1302-20 20 µg
$595.00
More Sizes Get Quote

Product Details

Alternate Name Insulin preproprotein , IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10
Gene Symbol INS
Gene ID 3630
Accession # NP_000198
Source E.coli
Appearance Liquid
Physical Form Description In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol
Molecular Weight 11.8 kDa (109 aa), confirmed by MALDI-TOF
Purity by SDS-PAGE ≥ 95%
Endotoxin Level < 1.0 EU per 1ug of protein (determined by LAL method)
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSFVNQHLC GSHLVEALYL VCGERGFFYT PKTRREAEDL QVGQVELGGG PGAGSLQPLA LEGSLQKRGI VEQCCTSICS LYQLENYCN
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

INS, also known as insulin preproprotein, is a biologically inactive precursor to the biologically active endocrine hormone insulin. Insulin is an essential hormone for maintaining metabolic homeostasis in the body. To make fully bioactive insulin, pancreatic beta cells initiate synthesis of INS. It is converted into proinsulin by signal peptidases, which remove its signal peptide from its N-terminus. Finally, proinsulin is converted into the bioactive hormone insulin by removal of the C-peptide. Recombinant human INS, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques.


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