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Product Details
| Alternate Name | 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; Sapanisertib; MLN0128 |
|---|---|
| Appearance | Off-white solid |
| CAS # | 1224844-38-5 |
| Molecular Formula | C₁₅H₁₅N₇O |
| Molecular Weight | 309.33 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>30 mg/ml) |
| SMILES | CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N |
| InChi | InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19) |
| InChi Key | GYLDXIAOMVERTK-UHFFFAOYSA-N |
| PubChem CID | 45375953 |
| MDL Number | MFCD22124893 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
INK-128 is a potent, selective and ATP-competituve mTORC1/2 inhibitor with potential anticancer properties. Displays >200-fold less selectivity towards class I PI3-K isoforms. Recently, it has been shown that INK-128 can also suppress HIV-1 in humanized mice.
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