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INK-128

A potent mTOR inhibitor
Catalog #: 9527
SKU-Size Size Price Qty
9527-5 5 mg
$125.00
9527-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; Sapanisertib; MLN0128
Appearance Off-white solid
CAS # 1224844-38-5
Molecular Formula C₁₅H₁₅N₇O
Molecular Weight 309.33
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N
InChi InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
InChi Key GYLDXIAOMVERTK-UHFFFAOYSA-N
PubChem CID 45375953
MDL Number MFCD22124893
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

INK-128 is a potent, selective and ATP-competituve mTORC1/2 inhibitor with potential anticancer properties. Displays >200-fold less selectivity towards class I PI3-K isoforms. Recently, it has been shown that INK-128 can also suppress HIV-1 in humanized mice.


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