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INH6

A potent inhibitor of Hec1/Nek2
Catalog #: B2907
SKU-Size Size Price Qty
B2907-1 1 mg
$85.00
B2907-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name N-[4-(2,4,6-trimethylphenyl)-1,3-thiazol-2-yl]benzamide; N-(4-mesitylthiazol-2-yl)benzamide; Hec1/Nek2 Mitotic Pathway Inhibitor II
Appearance A crystalline solid
CAS # 1001753-24-7
Molecular Formula C₁₉H₁₈N₂OS
Molecular Weight 322.42
Purity ≥98%
Solubility ~30 mg/ml in DMF
~20 mg/ml in DMSO
~1 mg/ml in Ethanol
SMILES CC1=CC(=C(C(=C1)C)C2=CSC(=N2)NC(=O)C3=CC=CC=C3)C
InChi InChI=1S/C19H18N2OS/c1-12-9-13(2)17(14(3)10-12)16-11-23-19(20-16)21-18(22)15-7-5-4-6-8-15/h4-11H,1-3H3,(H,20,21,22)
InChi Key WCZLNJTXHZPHLM-UHFFFAOYSA-N
PubChem CID 7918451
MDL Number MFCD04722622
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

INH6 is a potent inhibitor of Hec1/Nek2 which regulate the mitotic spindle formation together. It causes chromosome mis-alignment, apoptosis and cell death. It inhibits proliferation of MDA-MB231, MDA-MB468, HeLa and K562 cells with IC₅₀ values of 1.7 and 2.1, 2.4, and 2.5 µM respectively.


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