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A protein kinase C (PKC) activator
Catalog #: 2527
SKU-Size Size Price Qty
2527-1 1 mg
2527-5 5 mg
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Product Details

Alternate Name (1aR,​2S,​5R,​5aR,​6S,​8aS,​9R,​10aR)-​1a,​2,​5,​5a,​6,​9,​10,​10a-​octahydro-​5,​5a,​6-​trihydroxy-​4-​(hydroxymethyl)-​1,​1,​7,​9-​tetramethyl-​1H-​2,​8a-​methanocyclopenta[a]cyclopropa[e]cyclodecen-​11-​one
Appearance Pale yellow solid
CAS # 30220-46-3
Molecular Formula C₂₀H₂₈O₅
Molecular Weight 348.44
Purity ≥98% by HPLC
Solubility DMSO or EtOH
InChi InChI=1S/C20H28O5/c1-9-7-19-10(2)5-13-14(18(13,3)4)12(17(19)24)6-11(8-21)16(23)20(19,25)15(9)22/h6-7,10,12-16,21-23,25H,5,8H2,1-4H3/t10-,12+,13-,14+,15+,16-,19+,20-/m1/s1
PubChem CID 442042
MDL Number MFCD00056380
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ingenol is a diterpenoid related to phorbol that acts as a weak protein kinase C (PKC) activator that displays a Ki value of 30 μM and an ED₅₀ value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.

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