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Inflammasome Pathway

The inflammasomes are multiprotein intracellular oligomers of the innate immune system, when activated, promotes the maturation and secretion of pro-inflammatory cytokines. Inflammasomes are known to detect pathogenic microorganisms and sterile stressors. It also induces a form of cell death called pyroptosis-a highly inflammatory form of programmed cell death with infection. Dysregulation of inflammasomes can lead to variety of autoimmune, neurodegenerative and metabolic disorders.

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