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Inducible NOS, Mouse Recombinant

Involved in various inflammatory conditions
Catalog #: P1667
SKU-Size Size Price Qty
P1667-10 10 µg
$255.00
P1667-50 50 µg
$425.00
More Sizes Get Quote

Product Details

Alternate Name Inducible Nitric Oxide Synthase; iNOS; NOS2
Gene ID 18126
Accession # P29477
Source E.coli
Appearance Sterile Filtered colorless solution
Physical Form Description Liquid
Molecular Weight 131.6 kDa with N-terminal His tag
Purity by SDS-PAGE > 80%
Formulation In 40 mM Bis-Tris, pH 7.5, 1 mM L-Arginine, 3 mM DTT, 4 µM Tetrahydrobiopterin, and 10% glycerol
Amino Acid Sequence aa 1-1144 (P29477)
Specific Activity ≥ 100 mU/mg. Measured by its ability to convert L-arginine to nitric oxide and L-citrulline by using BioVision’s Nitric Oxide Synthase (NOS) Activity Assay Kit (Cat. No. K205).
Unit Definition One unit of NOS is defined as the amount of enzyme that generates 1 µmol of nitric oxide per min at 37 °C under the assay conditions.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70 °C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.

Details

Inducible nitric oxide synthase (iNOS), also known as inflammatory nitric oxide synthase, is a calcium independent isoenzyme involved in synthesis of nitric oxide (NO). It is a soluble enzyme encoded by the gene mapped to mouse chromosome 11. iNOS is active in dimeric form and its activity is induced by cytokines and various other stimuli, including lipopolysaccharide. iNOS is expressed in various inflammatory conditions and enhances the synthesis of proinflammatory mediators such as IL-6 and IL-8.


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