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A potent and selective BET inhibitor
Catalog #: B2438

In stock

SKU-Size Size Price Qty
B2438-1 1 mg
B2438-5 5 mg
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Product Details

Appearance Crystalline solid
CAS # 1820889-23-3
Molecular Formula C₂₀H₂₁N₃O₅S
Molecular Weight 415.46
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES CC1(C(=O)N(C2=C(O1)C(=CC(=C2)S(=O)(=O)C)C3=CN(C(=O)C4=C3C=CN4)C)C)C
InChi InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5,26)27)8-13(17(15)28-20)14-10-22(3)18(24) 16-12(14)6-7-21-16/h6-10,21H,1-5H3
PubChem CID 118467751
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


INCB057643 is a potent and selective BET inhibitor; displays more effectivity against androgen-dependent (VCaP and LNCaP) than androgen-independent (DU145 and PC3) cells with IC50 of <100 nM and >500 nM, respectively; significantly causes inhibition of tumor growth in mice bearing 22Rv1 tumor xenografts. INCB057643 inhibits proliferation of prostate cancer cell lines.

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