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INCB-024360

A potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor
Catalog #: 9477
SKU-Size Size Price Qty
9477-5 5 mg
$175.00
9477-25 25 mg
$665.00
More Sizes Get Quote

Product Details

Alternate Name (E)-N’-(3-bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxadiazole-3-carboxamide); Epacadostat; INCB24360
Appearance White to off-white solid
CAS # 1204669-58-8
Molecular Formula C₁₁H₁₃BrFN₇O₄S
Molecular Weight 438.23
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES C1=CC(=C(C=C1N/C(=C\2/C(=NON2)NCCNS(=O)(=O)N)/N=O)Br)F
InChi InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16-17,19H,3-4H2,(H,15,20)(H2,14,22,23)/b11-9+
InChi Key YPBKTZBXSBLTDK-PKNBQFBNSA-N
PubChem CID 44608567
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

INCB-024360 is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor ( IC₅₀ = 10 nM); displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Exhibits potent in vitro and in vivo immunomodulating and antineoplastic activities


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