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Importazole

An inhibitor of the transport receptor importin-β
Catalog #: B2958
SKU-Size Size Price Qty
B2958-5 5 mg
$105.00
B2958-25 25 mg
$420.00
More Sizes Get Quote

Product Details

Alternate Name N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine; IPZ
Appearance Solid
CAS # 662163-81-7
Molecular Formula C₂₀H₂₂N₄
Molecular Weight 318.42
Purity >98%
Solubility ~5 mg/ml in Ethanol, ~30 mg/ml in DMSO and DMF
SMILES CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)N4CCCC4
InChi InChI=1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)
InChi Key HKGJEZIGDHFJFL-UHFFFAOYSA-N
PubChem CID 2949965
MDL Number MFCD04077630
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Importazole is a 2,4-diaminoquinazoline that inhibits the function of transport receptor importin-β, likely by altering its interaction with RanGTP. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells with an IC₅₀ of 15 μM, which is reversible upon importazole washout. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and NF-κB in multiple myeloma cells. It induces apoptosis and inhibits growth of multiple myeloma cell lines with IC₅₀ values of 4.4 μM and 4.8 μM, respectively. It also induces defects in astral MT dynamics and misoriented spindles.


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