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An activator of AMPK and an inhibitor of mitochondrial complex I
Catalog #: B3126
SKU-Size Size Price Qty
B3126-5 5 mg
B3126-25 25 mg
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Product Details

Alternate Name HL156A, N'-[N'-[4-(trifluoromethoxy)phenyl]carbamimidoyl]pyrrolidine-1-carboximidamide; N-(Imino((4-(trifluoromethoxy)phenyl)amino)methyl)-1-pyrrolidinecarboximidamide
Appearance White to off-white solid powder
CAS # 1422365-93-2
Molecular Formula C₁₃H₁₆F₃N₅O
Molecular Weight 315.29
Purity ≥ 98%
Solubility 60 mg/ml in DMSO
InChi InChI=1S/C13H16F3N5O/c14-13(15,16)22-10-5-3-9(4-6-10)19-11(17)20-12(18)21-7-1-2-8-21/h3-6H,1-2,7-8H2,(H4,17,18,19,20)
PubChem CID 71512108
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


IM156 is a bioenergetic biguanide derivative which blocks mitochondrial complex I and an activator of AMP-activated protein kinase (AMPK). It is a derivative of metformin. IM156 causes energy depletion in tumor cells by inhibiting oxidative phosphorylation. IM156 at a concentration of 15 μM in combination with temozolomide decreases the stemness and invasive properties of glioblastoma tumorspheres. IM156 is in phase I clinical trials for advanced solid tumors and lymphoma.

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