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IM-12

A potent and selective GSK-3β inhibitor
Catalog #: 2822

In stock

SKU-Size Size Price Qty
2822-5 5 mg
$85.00
2822-25 25 mg
$345.00
More Sizes Get Quote

Product Details

Alternate Name 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Appearance Yellow orange solid
CAS # 1129669-05-1
Molecular Formula C₂₂H₂₀FN₃O₂
Molecular Weight 377.41
Purity ≥98% by HPLC
Solubility DMSO (25 mg/ml) or EtOH (5 mg/ml)
SMILES CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F
InChi InChI=1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
InChi Key ZKJAZFUFPPSFCO-UHFFFAOYSA-N
PubChem CID 25209788
MDL Number MFCD20527313
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IM-12 is a potent and selective GSK-3β inhibitor (IC₅₀ = 53 nM). It significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling.


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