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ILK1 Antibody

based on 1 citations in multiple journalsILK1 Antibody14.1 4
Catalog #: 3423
SKU-Size Size Price Qty
3423-30T 30 µg
$89.00
3423-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target ILK1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to the C-terminus of human ILK-1
Accession # NP_034692
Gene ID 16202
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry
Application & Usage Western blotting (0.5-4 µg/ml), Immunohistochemistry (10-20 µg/ml, frozen & paraffin). However, the optimal concentrations should be determined individually. The antibody recognizes 59 kDa of ILK1 from samples of human, mouse, and rat origins. Reactivity
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ILKs (Integrin-linked kinases) in combination with integrins and growth factors regulate cell survival, cell cycle, cell-cell adhesion and cell motility. ILK functions as a scaffold bridging the extra-cellular matrix (ECM) and growth factor receptors to the actin cytoskeleton throμgh interactions with integrin, PINCH (which links ILK to the RTKs via Nck2), CH-ILKBP and affixin. ILK phosphorylates several cellular targets including Akt, GSK-3, myosin light chain 2, as well as affixin. These phosphorylation events are key regulatory steps in modulating the activities of the targets.


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Xinying Hu et al., Rosuvastatin Changes Cytokine Expressions in Ischemic Territory and Preserves Heart Function After Acute Myocardial Infarction in Rats. Journal of Cardiovascular Pharmacology and Therapeutics, Mar 2013; 18: 162 - 176.
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