Product Details
| abID | ab285830 |
|---|---|
| Cat # +Size | 7324-100 |
| Size | 100 μg |
| Alternate Name | Interleukin-18-binding protein, IL18BPa |
| Gene Symbol | IL18BP |
| Gene ID | 10068 |
| Accession # | O95998 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol. |
| Molecular Weight | 20 kDa (187 aa, 31-194 aa + His Tag), confirmed by MALDI-TOF. |
| Purity by SDS-PAGE | ≥90% |
| Endotoxin Level | < 1.0 EU per 1 microgram of protein |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.
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