IL17 A/F, Rat Recombinant

Induces the production of a variety of chemokines
Catalog #: 7587 | abID: ab285915

Product Details

abID ab285915
Alternate Name Interleukin 17 A/F, IL-17A, IL-17F, Interleukin 17A, Interleukin 17F
Gene Symbol IL17 A/F
Gene ID 301289/ 301291.
Accession # Q61453/Q5BJ95
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized without any additives.
Molecular Weight 30.7 kDa.
Purity by SDS-PAGE ≥98%
Endotoxin Level Measured by kinetic LAL analysis and is typically ≤ 1 EU/μg protein
Biological Activity The activity determined by the dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts, is typically 20-30 ng/mL.
Reconstitution Instructions Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a conce
Amino Acid Sequence IL-17A subunit: MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS
IL-17F subunit: MARRNPKVGL SALQKAGNCP PLEDNSVRVD IRIFNQNQGI SVPRDFQNRS SSPWD YNITR DPDR
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant rat IL-17AF is a non-glycosylated, disulfide-linked heterodimer. It is comprised of one monomeric subunit each of IL-17A and IL-17F, having a total of 269 amino acids and a molecular weight of 30.7 kDa.


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