Product Details
| abID | ab109674 |
|---|---|
| Alternate Name | Interleukin 17 A/F, IL-17A, IL-17F, Interleukin 17A, Interleukin 17F |
| Gene Symbol | IL17 A/F |
| Gene ID | 16171/257630 |
| Accession # | Q62386/Q7TN17 |
| Source | E. coli |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized without any additives. |
| Molecular Weight | 30.7 kDa. |
| Purity by SDS-PAGE | ≥98% |
| Endotoxin Level | Measured by kinetic LAL analysis and is typically ≤ 1 EU/μg protein |
| Biological Activity | The activity determined by the dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts, is typically 75-325 ng/mL. |
| Reconstitution Instructions | Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a conce |
| Amino Acid Sequence | IL-17A subunit: MAAIIPQSSACPNT EAKDFLQNVKVNLKVFNSL GAKVSSRRPSDYLNRSTSPW TLHRNEDPDRYPSVIW EAQCRHQRCVNAEGKL DHHMNSVLIQQEILVL KREPESCPFTFRVEKML VGVGCTCVASIVRQAA IL-17F subunit: MRKNPKAGVPALQKAGNC PPLEDNTVRVDIRIFNQ NQGISVPREFQNRSSSPW DYNITRDPHRFPSEIAEA QC |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant mouse IL-17AF is a non-glycosylated, disulfide-linked heterodimer. It is comprised of one monomeric subunit each of IL-17A and IL-17F, having a total of 271 amino acids and a molecular weight of 30.7 kDa.
Why buy BioVision Products?
 |
 |
 |
 |
Innovation |
Affordability |
Global Presence |
Technical Support |
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways. |
BioVision is committed to providing the highest quality products at a competitive price. |
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery. |
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently. |
