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IL-6, murine recombinant

An important mediator of acute phase response
Catalog #: 4144
SKU-Size Size Price Qty
4144-10 10 μg
$225.00
4144-50 50 μg
$750.00
4144-1000 1 mg
$5,355.00
More Sizes Get Quote

Product Details

Alternate Name IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2, IL-6, Interleukin HP-1, B-cell hybridoma growth factor, B-cell stimulatory factor 2, CTL differentiation factor, Interferon beta-2.
Gene Symbol IL6
Gene ID 16193
Accession # P08505
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized with no additives.
Molecular Weight 21.7 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of the IL-6 dependent murine 7TD1 cells is <0.02 ng/ml, corresponding to a specific activity of >5 x 10⁷ units/mg.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.


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