Product Details
| abID | ab269185 |
|---|---|
| Alternate Name | Interleukin-5, IL-5, B-cell growth factor II, BCGF-II, Cytotoxic T-lymphocyte inducer, Eosinophil differentiation factor, T-cell replacing factor, TRF, Interleukin 5, IL-5, IL 5, IL-5, |
| Gene Symbol | IL5 |
| Gene ID | 16191 |
| Accession # | P04401 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized from 20 mM Sodium phosphate buffer, pH 7.5 |
| Molecular Weight | 26.2 kDa |
| Purity by SDS-PAGE | ≥97% |
| Purity by | ≥97% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | Mouse IL-5 is fully biologically active as compared to standard. The ED₅₀, as calculated by the dose-dependent induction of TF-1 cell proliferation, is 1.7ng/ml. |
| Reconstitution Instructions | It is recommended to reconstitute the lyophilized product with sterile H₂O at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Mouse Interleukin-5 (mIL-5) is a glycoprotein also known as EDF and TRF. It is involved in B-cell growth and eosinophil activation. IL-5 has been shown to be expressed in Th2, mast cells and eosinophils and is regulated by GATA-3, in addition to other transcription factors. IL-5 signals its biological effect through interaction with the IL-5 receptor (IL-5R). Recombinant mIL-5 is produced in E.Coli, comprised of two 113 amino acid chains forming a disulfide-linked homodimer with a molecular weight of 26.2 kDa.
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