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IL-37 (Human) ELISA Kit

A highly sensitive sandwich ELISA kit for the quantitative measurement of IL-37

WARNING: This product can expose you to chemicals including Sulfuric acid and TMB, which are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.
Catalog #: E5065
$725.00

Product Details

Cat # +Size E5065-100
Size 96 assays
Detection Method Absorbance is measured at 450 nm
Species Reactivity Human
Applications The ELISA kit is used for the quantitative detection of IL-37 in serum, plasma, tissue homogenates and other biological fluids
Features & Benefits ● Sensitivity: 18.75 pg/ml
● Recovery Rate: 89-99% for serum, 85-101% for EDTA plasma and 92-104% for heparin plasma
● Detection range: 31.25-2000 pg/ml
● Assay Precision; Intra-Assay CV < 8% and Inter-Assay < 10%
● Highly sensitive and specific
Kit Components ● ELISA Microplate
● Wash Buffer (25X)
● Plate Sealers
● Lyophilized Standard (2000 pg)
● Sample/Standard Dilution Buffer
● Biotin-labeled Antibody (Concentrated)
● Antibody Dilution Buffer
● HRP-Streptavidin Conjugate (SABC)
● SABC Dilution Buffer
● TMB Substrate
● Stop Solution
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Interleukin-37 (IL-37) belongs to the IL-1 family of cytokines which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. The IL-37 gene is in the human located on the long chromosome arm of chromosome 2. During inflammation, IL-37 restores the metabolism of the cell by reducing succinate, inhibiting mTOR, and activating AMPK. IL-37 levels are abnormal in patients with inflammatory and autoimmune diseases. BioVision’s IL-37 (Human) ELISA Kit is used for the quantitative detection of IL-37 in serum, plasma, tissue homogenates and other biological fluids. It is based on the principle of sandwich ELISA. The capture antibody is pre-coated on 96-well plates. The standards, test samples and biotin conjugated detection antibody are added to the wells subsequently, and washed with wash buffer. HRP-Streptavidin is added and unbound conjugates are washed away with wash buffer. The HRP enzymatic reaction is detected using TMB-substrate. Finally, an acidic stop solution terminates the enzymatic reaction. The color developed is directly proportional to the amount of IL-37 in the sample.


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