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IL-18 Antibody

Catalog #: 5180R
$310.00

Product Details

Cat # +Size 5180R-100
Size 100 µg
Antibody Target IL-18
Alternate Name IL-18, IL18, IL 18, Interluekin-18, Interluekin 18, interluekin
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide of mouse IL-18
Accession # P70380
Gene ID 16173
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-mouse IL-18 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Mouse
Application Western blot, Immunoprecipitation, Neutralization
Application & Usage Western blot analysis (0.5-4 µg/ml), immunoprecipitation (2-5 µg/ml), and neutralization (2-5 µg/ml). However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IL-18 (IFN-gamma-inducing factor, IGIF) is a novel proinflammatory cytokine that aμgments natural killer (NK) activity in spleen cells. It also has other biological properties such as activation of NF-kB, stimulation of Fas ligand expression, induction of CC and CXC chemokines. IL-18 increases production of competent HIV. IL-18 is related to the IL-1 family. One of the IL-18 receptor chains is the IL-1 receptor-related protein, a member of the IL-1R family. Like IL-1β, IL-18 is first synthesized as a leaderless precursor requiring the IL-1β converting enzyme (ICE) for cleavage into an active molecule. IL-18 may play a role in tissue injury in inflammatory reactions.


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Douglas et al., The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.  J. Immunol., Sep 2015; 195: 2365 - 2373.
Du et al., Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism. Mol. Cell. Biol., Aug 2015; 35: 2771 - 2789.
Cieniewicz et al., Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture. J. Virol., Jul 2015; 89: 6562 - 6574.
Baum et al., AIM2 and Endosomal TLRs Differentially Regulate Arthritis and Autoantibody Production in DNase II–Deficient Mice. J. Immunol., Feb 2015; 194: 873 - 877.
Wilson et al., Inflammasome-Dependent and -Independent IL-18 Production Mediates Immunity to the ISCOMATRIX Adjuvant.J. Immunol., Apr 2014; 192: 3259 - 3268.
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