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IL-17A Antibody

Polyclonal antibody to detect IL-17A in human samples
Catalog #: 5108
$245.00

Product Details

Cat # +Size 5108-50
Size 50 µg
Antibody Target IL-17A
Alternate Name CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte associated antigen 8
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen E.coli derived Recombinant Human IL-17A
Accession # Q16552
Gene ID 3605
Appearance Liquid
Formulation A sterile filtered antibody solution in PBS, pH 7.2.
Purification Affinity chromatography
Species Reactivity Human
Application Western blot, ELISA, Neutralization, Immunohistochemistry
Positive Control ELISA: Recombinant hIL-17A (Cat # 4176)IHC: Human breast invasive ductal carcinoma tissue section
Application & Usage 1) WB: Use 0.1-0.2 µg/ml. The detection limit for recombinant human IL-17A is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
2) ELISA: Use 0.5 - 2.0 μg/ml (100 μl/well antibody solution)
3) Neutralization: To yield one-half maxi
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells.


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