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IL-10, murine recombinant

An anti-inflammatory cytokine
Catalog #: 4156
SKU-Size Size Price Qty
4156-10 10 μg
$180.00
4156-50 50 μg
$595.00
4156-1000 1 mg
$4,800.00
More Sizes Get Quote

Product Details

Alternate Name B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor.
Gene Symbol IL10
Gene ID 16153
Accession # P18893
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from 3 mM Tris, pH 8.0
Molecular Weight 18.7 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ determined by the dose-dependent co-stimulation (with murine IL-4) of MC/9 cells is <2 ng/ml, corresponding to a specific activity of > 5 x 10⁵ units/mg.
Reconstitution Instructions Reconstitute in 3 mM Tris, pH 8.0 to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-Ą. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.


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