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IL-10, human recombinant

based on 3 citations in multiple journalsIL-10, human recombinant34.1 4
An anti-inflammatory cytokine
Catalog #: 4155
SKU-Size Size Price Qty
4155-10 10 μg
$180.00
4155-50 50 μg
$595.00
4155-1000 1 mg
$4,800.00
More Sizes Get Quote

Product Details

Alternate Name B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor.
Gene Symbol IL10
Gene ID 3586
Accession # P22301
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from PBS
Molecular Weight 19.6 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ determined by the dose-dependent co-stimulation (with murine IL-4) of MC/9 cells is < 2 ng/ml, corresponding to a specific activity of > 5 x 10⁵ units/mg.
Reconstitution Instructions Reconstitute in H₂O a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL-10 (Interleukin-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF), is an 18.6 kDa protein containing 161 amino acid residues. It shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI. The reported biological activities of IL-10 include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hypersensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production.


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Phadnis-Moghe et al., Suppression of Human B Cell Activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Involves Altered Regulation of B Cell Lymphoma-6. Toxicol. Sci., Mar 2015; 144: 39 - 50.
Galdo, F. D. et. al. NF B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis. Ann Rheum Dis, Nov 2010; 69: 2024 - 2033.
Van der Vliet HJ et al (2008) J. Immunol. 180: 7287-7293.
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