IL-1 RA, human recombinant

A natural inhibitor of the pro-inflammatory effect of IL1β
Catalog #: 4263 | abID: ab119745

Product Details

abID ab119745
Alternate Name IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, MGC10430
Gene Symbol IL-1RA
Gene ID 3557
Accession # P18510
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized without additves
Molecular Weight 17.0 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Biological Activity The ED₅₀ as determined by the dose-dependent inhibition of IL-1 stimulation of D10S cells was found to be 0.5 ng/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile H₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Amino Acid Sequence The sequence of the first five N-terminal amino acids was determined and was found to be Met-Arg-Pro-Ser-Gly.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1RA Human Recombinant produced in E.Coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton. The IL1RA is purified by proprietary chromatographic techniques.


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