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IL-1 beta, rat recombinant

based on 1 citations in multiple journalsIL-1 beta, rat recombinant14.1 4
An important mediator of inflammatory responses
Catalog #: 4130
SKU-Size Size Price Qty
4130-10 10 μg
$230.00
4130-50 50 μg
$715.00
4130-1000 1 mg
$6,240.00
More Sizes Get Quote

Product Details

Alternate Name Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Gene Symbol IL1B
Gene ID UniGene:Rn.9869
Accession # Q63264
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and then lyophilized from 10 mM Sodium Acetate, pH 6.5
Molecular Weight 17.3 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the dose-dependent stimulation of murine D10S cells is <0.1 ng/ml, corresponding to a specific activity of >1 x 10⁷ units/mg.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at +4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, B-cell maturation and proliferation, mitogenic FGF-like activity and stimulation of the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues.


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Yang, Z.F. et al. (2004) J. Immunol. 173:2507-2515.
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