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IL-1 beta, murine recombinant

An important mediator of inflammatory responses
Catalog #: 4129
SKU-Size Size Price Qty
4129-10 10 μg
$180.00
4129-50 50 μg
$595.00
4129-1000 1 mg
$4,250.00
More Sizes Get Quote

Product Details

Alternate Name Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Gene Symbol IL1B
Gene ID 16176
Accession # P10749
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from 5 mM Tris, pH 8.0
Molecular Weight 17.5 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ determined by the dose-dependent stimulation of murine D10S cells is <0.002 ng/ml, corresponding to a specific activity of >5 x 10⁸ units/mg.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1 µg/µl. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues.


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