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Product Details
| Alternate Name | Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) |
|---|---|
| Gene Symbol | IL1B |
| Gene ID | 3553 |
| Accession # | P01584 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized with no additives. |
| Molecular Weight | 17.0 kDa |
| Purity by SDS-PAGE | ≥98% |
| Purity by | ≥98% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by murine C3H/HeJ thymocytes is <0.1 ng/ml, corresponding to a specific activity of >1 x 10⁷ units/mg. |
| Reconstitution Instructions | We recommend a quick spin followed by reconstitution in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or stored at –20°C for future use. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
IL-1β is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses including the activation of B and T cells. Recombinant human IL-1β is a 17.0 kDa protein containing 153 amino acid residues.
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Hui et al., Individual Cytokines Modulate the Neurological Symptoms of ATMDeficiency in a Region Specific Manner. eNeuro, Jul 2015; 2: ENEURO.0032-15.2015
Burg et al., Activated group 3 innate lymphoid cells promote T-cell–mediated immune responses. PNAS, Sep 2014; 111: 12835 - 12840.
J. Michelle Kahlenberg et al., Inflammasome Activation of IL-18 Results in Endothelial Progenitor Cell Dysfunction in Systemic Lupus Erythematosus, J. Immunol., Dec 2011; 187: 6143 - 6156.
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