IL-1 beta, human recombinant

An important mediator of inflammatory responses
Catalog #: 4128 | abID: ab285499

Product Details

abID ab285499
Alternate Name Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Gene Symbol IL1B
Gene ID 3553
Accession # P01584
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized with no additives.
Molecular Weight 17.0 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by murine C3H/HeJ thymocytes is <0.1 ng/ml, corresponding to a specific activity of >1 x 10⁷ units/mg.
Reconstitution Instructions We recommend a quick spin followed by reconstitution in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or stored at –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


IL-1β is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses including the activation of B and T cells. Recombinant human IL-1β is a 17.0 kDa protein containing 153 amino acid residues.

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Hui et al., Individual Cytokines Modulate the Neurological Symptoms of ATMDeficiency in a Region Specific Manner. eNeuro, Jul 2015; 2: ENEURO.0032-15.2015
Burg et al., Activated group 3 innate lymphoid cells promote T-cell–mediated immune responses. PNAS, Sep 2014; 111: 12835 - 12840.
J. Michelle Kahlenberg et al., Inflammasome Activation of IL-18 Results in Endothelial Progenitor Cell Dysfunction in Systemic Lupus Erythematosus,  J. Immunol., Dec 2011; 187: 6143 - 6156.
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