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IL-1 beta Antibody

based on 4 citations in multiple journalsIL-1 beta Antibody44.1 4
Catalog #: 5129
SKU-Size Size Price Qty
5129-30T 30 µg
$89.00
5129-100 100 µg
$300.00
More Sizes Get Quote

Product Details

Antibody Target IL-1b
Alternate Name IL-1 beta, IL1 beta, IL 1 beta, Interluekin-1 beta, Interluekin 1 beta, interluekin
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen E. coli expressed murine IL-1β
Accession # CAA28637
Gene ID 52667
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation Affinity purified rabbit anti-murine IL-1β polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5%BSA, 5 mM EDTA and 0.03% proclin
Purification Affinity purified
Species Reactivity Mouse
Application Western blot, Neutralization
Application & Usage Western blot analysis (0.5-4 µg/ml). Recombinant murine IL-1β (Cat.# 4129-10) can be used as a positive control. Per researcher’s feedback, the antibody can also be used in neutralization studies. However, the optimal conditions should be determined indiv
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IL-1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine. Recombinant murine IL-1beta is a 17.5 kDa protein containing 153 amino acid residues.


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Wang et al., AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages. Ann Rheum Dis, Oct 2014; 10.1136/annrheumdis-2014-206074.
Zhirong Zhang et al., Gene Deletion of Gabarap Enhances Nlrp3 Inflammasome-Dependent Inflammatory Responses. J. Immunol., Apr 2013; 190: 3517 - 3524.
Sozen T et al (2009) Stroke; 40: 2519 - 2525.
Scott P. et al. (2006) J. Immunol. 177: 6370-6378.
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