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IKK16

IKK-16 is a potent and selective inhibitor of IκB kinase (IKK)
Catalog #: B1087
SKU-Size Size Price Qty
B1087-5 5 mg
$135.00
B1087-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name [4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone, hydrochloride
Appearance Beige solid
CAS # 1186195-62-9
Molecular Formula C₂₈H₃₀ClN₅OS
Molecular Weight 520.09
Purity ≥98% by HPLC
Solubility DMSO (50 mg/ml)
SMILES C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl
InChi InChI=1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H
InChi Key XFVDIVQCZWDBCW-UHFFFAOYSA-N
PubChem CID 56972179
MDL Number MFCD09971091
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IKK-16 is a potent and selective inhibitor of IκB kinase (IKK) with IC₅₀ values from 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. It is effective in cells and in animals and has been used delineate the role of NF-κB signaling in diverse contexts. IKK-16 has also been reported to inhibit protein kinase D isoforms and the ATP-binding cassette (ABC) transporter ABCB1.


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