IKK-ε Kinase Inhibitor II

An IKK-ε kinase inhibitor
Catalog #: 1811 | abID: ab142109

Product Details

abID ab142109
Alternate Name 5-​(5,​6-​dimethoxy-​1H-​benzimidazol-​1-​yl)-​3-​[[2-​(methylsulfonyl)phenyl]methoxy]-​2-​thiophenecarbonitrile
Appearance Crystalline solid
CAS # 862812-98-4
Molecular Formula C₂₂H₁₉N₃O₅S₂
Molecular Weight 469.53
Purity ≥97% by HPLC
Solubility DMSO
SMILES COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C#N)OCC4=CC=CC=C4S(=O)(=O)C)OC
InChi InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)292)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3
InChi Key LDTAHRLHGHFHKP-UHFFFAOYSA-N
PubChem CID 11626927
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A benzimidazole analog that acts as a potent and selective inhibitor of IKK-ε kinase (IC₅₀ = 40 nM); displays >125-fold selectivity over IKK-α and IKK-β.


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Palchetti et al., Transfected Poly(I:C) Activates Different dsRNA Receptors, Leading to Apoptosis or Immunoadjuvant Response in Androgen-independent Prostate Cancer Cells. J. Biol. Chem., Feb 2015; 290: 5470 - 5483.
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