Product Details
| abID | ab142109 |
|---|---|
| Alternate Name | 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile |
| Appearance | Crystalline solid |
| CAS # | 862812-98-4 |
| Molecular Formula | C₂₂H₁₉N₃O₅S₂ |
| Molecular Weight | 469.53 |
| Purity | ≥97% by HPLC |
| Solubility | DMSO |
| SMILES | COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C#N)OCC4=CC=CC=C4S(=O)(=O)C)OC |
| InChi | InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)292)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3 |
| InChi Key | LDTAHRLHGHFHKP-UHFFFAOYSA-N |
| PubChem CID | 11626927 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A benzimidazole analog that acts as a potent and selective inhibitor of IKK-ε kinase (IC₅₀ = 40 nM); displays >125-fold selectivity over IKK-α and IKK-β.
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Palchetti et al., Transfected Poly(I:C) Activates Different dsRNA Receptors, Leading to Apoptosis or Immunoadjuvant Response in Androgen-independent Prostate Cancer Cells. J. Biol. Chem., Feb 2015; 290: 5470 - 5483.
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