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IkBalpha Antibody

Catalog #: 3252
$245.00

Product Details

Cat # +Size 3252-100
Size 100 µg
Antibody Target IkBalpha
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen E. coli expressed mouse IkBa
Accession # Q9Z1E3
Gene ID 61226507
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) affinity-purified rabbit anti-IkB-alpha polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Mouse
Application Western blot
Application & Usage Western blot (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Cross-reactivity to IkB-alpha of other species has not been determined.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IkB-alpha protein is a NF-kB inhibitory protein. It binds NF-kB and retains the complex in the cytoplasm, thereby preventing it from entering into nucleus and functioning as a transcription factor. Upon receiving a variety of signals, IkB-alpha undergoes phosphorylation at serine residues by an ubiquitin-dependent protein kinases and finally degraded by the proteasome. Free NF-kB then binds DNA and affects gene expression.


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