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IkBalpha Antibody (Clone 6A055)

Catalog #: 3315
$295.00

Product Details

Cat # +Size 3315-100
Size 100 µg
Antibody Target IkBalpha
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Recombinant human IkBa
Accession # P25963
Gene ID 4792
Appearance Colorless liquid
Concentration 0.25 mg/ml
Formulation 100 µg (0.25 mg/ml) immunoaffinity purified mouse monoclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunoprecipitation, Immunohistochemistry
Application & Usage Western blotting (0.5-4 µg/ml) and immunoprecipitation (1-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects both phosphorylated and non-phosphorylated forms of IkBα.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/g. External stimuli such TNF-α or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first gene induced following NF-kB activation is IkBα.


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