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Product Details
| Alternate Name | N2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine, IITZ01 |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1807988-47-1 |
| Molecular Formula | C₂₆H₂₃FN₈O |
| Molecular Weight | 482.51 |
| Purity | ≥98% by HPLC |
| Solubility | >50 mg/ml in DMSO |
| SMILES | C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)F)NC4=CC=C(C=C4)C5=NC6=CC=CC=C6N5 |
| InChi | InChI=1S/C26H23FN8O/c27-18-7-11-20(12-8-18)29-25-32-24(33-26(34-25)35-13-15-36-16-14-35)28-19-9-5-17(6-10-19)23-30-21-3-1-2-4-22(21)31-23/h1-12H,13-16H2,(H,30,31)(H2,28,29,32,33,34) |
| InChi Key | XGEDDGLPNSLBFE-UHFFFAOYSA-N |
| PubChem CID | 134817273 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
IITZ-01 is a potent potent lysosomotropic autophagy inhibitor; displays >10-fold potent autophagy inhibition than Chloroquine (Cat. No.1825); enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. Displays potent anticancer activity.
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