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IGF-I, human recombinant

based on 3 citations in multiple journalsIGF-I, human recombinant34.1 4
Human IGF-1 from E.Coli, AOF, ≥98% pure, biologically active, cell culture tested
Catalog #: 4119
SKU-Size Size Price Qty
4119-100 100 μg
$110.00
4119-1000 1 mg
$255.00
4119-5000 5 mg
$795.00
4119-10MG 10 mg
$1,295.00
4119-20MG 20 mg
$1,995.00
4119-50MG 50 mg
$3,650.00
4119-1G 1 g
$36,000.00
More Sizes Get Quote

Product Details

Alternate Name Insulin-Like Growth Factor 1, Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF
Gene Symbol IGF1A
Gene ID 3479
Accession # P01343
Source E. coli
Appearance Recombinant IGF-1 is available as a lyophilized powder
Physical Form Description IGF-1 protein is lyophilized with no additives
Molecular Weight 7.6 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity EC50 is typically 21.6-54.7 ng/ml. The activity was determined using dose dependent stimulation of Balbc 3T3 cell line.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other buffered solutions or stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Human IGF-1 (insulin-like Growth Factor-1, IGF1, MGF, Somatomedin) is a hormone similar in molecular structure to insulin. It is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-1 binds to at least two cell surface receptors: the IGF-1 receptor (IGF1R), and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Mature human IGF I shares 94% and 96% aa sequence identity with mouse IGF1 and rat IGF1, respectively, and exhibits cross species activity. It shares 64% aa sequence identity with mature human IGFII. Human IGF-1 is a 7.6 kDa protein containing 70 amino acid residues. The recombinant human IGF-1 was produced using animal origin free technology.


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Wang et al,The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. Mol. Cancer Ther., Apr 2015; 14: 982 - 993.
Fotovati, A. et. al. YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth. Cancer Res., Aug 2011; 71: 5569 - 5578.
Wang, P. et al. Protein-Tyrosine Phosphatase alpha Acts as an Upstream Regulator of Fyn Signaling to Promote Oligodendrocyte Differentiation and Myyelination. J. Biol. Chem. 2009; 284: 33692-33702.
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