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IGF-BP6, human recombinant

Regulates the growth promoting effects of the IGFs on cell culture
Catalog #: 7350
$295.00

Product Details

Cat # +Size 7350-20
Size 20 μg
Alternate Name Insulin-like growth factor-binding protein 6, IBP6
Gene Symbol IGFBP6
Gene ID 3489
Accession # P24592
Source E. coli
Appearance Liquid
Physical Form Description 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 20% glycerol.
Molecular Weight 25 kDa (236 aa, 28-240 aa + His Tag), confirmed by MALDI-TOF.
Purity by SDS-PAGE ≥85%
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSRCPGCGQ GVQAGCPGGC VEEEDGGSPA EGCAEAEGCL RREGQECGVY TPNCAPGLQC HPPKDDEAPL RALLLGRGRC LPARAPAVAE ENPKESKPQA GTARPQDVNR RDQQRNPGTS TTPSQPNSAG VQDTEMGPCR RHLDSVLQQL QTEVYRGAQT LYVPNCDHRG FYRKRQCRSS QGQRRGPCWC VDRMGKSLPG SPDGNGSSSC PT
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

IGFBP6 contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Recombinant human IGFPB6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.


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