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IGF-BP5, human recombinant

A protein which binds and prolongs the half-life of the IGFs 
Catalog #: 4723
SKU-Size Size Price Qty
4723-25 25 μg
$190.00
4723-100 100 μg
$525.00
4723-1000 1 mg
$2,850.00
More Sizes Get Quote

Product Details

Alternate Name Insulin-like Growth Factor-Binding Protein5
Gene Symbol IBP5
Gene ID 3488
Accession # P24593
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized from 10 mM Sodium Citrate solution, pH 3.0.
Molecular Weight 28. 6 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is <0.3 mg/ml, in the presence of 15 ng/ml of human IGF-II.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Human IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by Vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole body growth inhibition, and retarded muscle development. Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.


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