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IGF-BP3, human recombinant

A protein which binds and prolongs the half-life of the IGFs 
Catalog #: 4720
SKU-Size Size Price Qty
4720-25 25 μg
$190.00
4720-100 100 μg
$525.00
4720-1000 1 mg
$2,850.00
More Sizes Get Quote

Product Details

Alternate Name Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein
Gene Symbol IBP3
Gene ID 3486
Accession # P17936
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized from 20 mM HCl
Molecular Weight 28.8 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is <0.2 mg/ml, in the presence of 15 ng/ml of human IGF-II.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
Amino Acid Sequence AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.


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