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IGF-BP2, human recombinant

Inhibits IGF-II action in human breast and ovarian carcinoma cells
Catalog #: 7165
SKU-Size Size Price Qty
7165-10 10 μg
$185.00
7165-50 50 μg
$815.00
More Sizes Get Quote

Product Details

Alternate Name IBP-2
Gene Symbol IGFBP2
Gene ID 3485
Accession # P18065
Source (BTI-Tn-5B1-4) Hi-5 Insect cells
Appearance Lyophilized powder
Physical Form Description Sterile filtered through a 0.2 micron filter. Lyophilized from 1 x PBS, pH 7.2.
Molecular Weight 31.5 kDa
Purity by SDS-PAGE ≥98%
Endotoxin Level < 0.1 ng/μg of protein (<1EU/μg).
Biological Activity Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carri
Amino Acid Sequence EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YN
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.


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