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IFN-gamma, murine recombinant

based on 1 citations in multiple journalsIFN-gamma, murine recombinant14.1 4
A critical cytokine for innate and adaptive immunity
Catalog #: 4117
SKU-Size Size Price Qty
4117-20 20 μg
4117-100 100 μg
4117-1000 1 mg
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Product Details

Alternate Name Immune Interferon-γ, type II interferon, T cell interferon, MAF
Gene Symbol IFNG
Gene ID 15978
Accession # P01580
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from 10 mM Na2PO4, pH 7.0 + 25 mM NaCl
Molecular Weight 15.6 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by a cytopathic affect inhibition assay with murine NIH 3T3 cells challenged with VSV virus is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 10⁷ units/mg.
Reconstitution Instructions Reconstitute in ddH₂O to a concentration of 1 mg/ml. Further dilutions should be made into RPMI + 10% FCS and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Recombinant murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.

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Kajiwara et al., A Critical Role for Human Caspase-4 in Endotoxin Sensitivity. J. Immunol., Jul 2014; 193: 335 - 343.
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