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iCRT14

A Wnt inhibitor
Catalog #: B2562
SKU-Size Size Price Qty
B2562-5 5 mg
$95.00
B2562-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name iCRT 14, Wnt inhibitor, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione, iCRT-14
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 677331-12-3
Molecular Formula C₂₁H₁₇N₃O₂S
Molecular Weight 375.45
Purity ≥98% by HPLC
Solubility ~2 mg/ml in DMSO
SMILES O=C(S/C1=C\C2=C(C)N(C3=CN=CC=C3)C(C)=C2)N(C4=CC=CC=C4)C1=O
InChi InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChi Key NCSHZXNGQYSKLR-UNOMPAQXSA-N
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

iCRT14 is a potent potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC₅₀ = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM). It inhibits Notch, hedgehog (Hh), and JAK/STAT signaling in reporter assays with IC50 values of 69.2, 194, and 70 nM, respectively.


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