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ICR-1 AM

A membrane permeable fluorescent calcium indicator
Catalog #: B3147
SKU-Size Size Price Qty
B3147-5PK 5 x 50 μg
$395.00
B3147-500 500 μg
$625.00
More Sizes Get Quote

Product Details

Alternate Name Calcium (Ca2⁺) indicator; ICR-1 membrane permeable; ICR-1 acetoxymethyl ester; Fluorescent Calcium indicator
Appearance Colorless powder
Molecular Weight 1190.49
Purity ≥ 90%
Solubility Soluble in DMSO
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ICR-1 is a red fluorescent calcium (Ca2+) indicator for intracellular Ca2+ measurements. It provides deeper tissue penetration and dramatic background reduction in tissues that have high autofluorescence, in the presence of serum or fluorescent compounds. ICR-1 can also be multiplexed with GFP-labeled cells or other green fluorophores. Unlike some other red fluorescent Ca2+ indicators, ICR-1 does not accumulate in the mitochondria. ICR-1 can be used for fluorescence lifetime imaging, multiphoton imaging and is ideal for most intracellular Ca2+ measurements. ICR-1 AM is the membrane permeable form of the calcium indicator. Masking the negative charge using non-polar, ester-linked moieties (AM ester) allows the molecule to enter cells through passive diffusion. Once inside the cell, ubiquitous intracellular esterase enzymes promote rapid hydrolysis of the AM ester leaving the active, highly polar form of the indicator trapped inside the cell. ICR-1 AM is optimal for cellular and tissue imaging applications due to the long-wavelength emission and a large Stokes shift which reduces contributions of autofluorescence. It binds to calcium with a Kd value of 480 nM and displays excitation/emission maxima of 580 nm/660 nm, respectively.


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