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ICG-001

A specific inhibitor of Wnt/β-catenin signaling pathway
Catalog #: 2275
SKU-Size Size Price Qty
2275-5 5 mg
$125.00
2275-25 25 mg
$485.00
More Sizes Get Quote

Product Details

Alternate Name (6S,9aS)-Hexahydro-6-[(4-hydroxyphe­nyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(­phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-c­arboxamide
Appearance White solid
CAS # 847591-62-2
Molecular Formula C₃₃H₃₂N₄O₄
Molecular Weight 548.63
Purity ≥98% by HPLC
Solubility DMSO (~50 mg/ml) or EtOH (~25 mg/ml)
SMILES C1CN(C2CN(C(=O)C(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
InChi InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/s1
InChi Key HQWTUOLCGKIECB-XZWHSSHBSA-N
PubChem CID 11238147
Handling Protect from air and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A specific inhibitor of Wnt/β-catenin signaling pathway. It down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein (CBP). ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.


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