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ICAM-3, Human Recombinant

Contributes to apoptotic neutrophil phagocytosis by macrophages
Catalog #: P1564

Product Details

Cat # +Size P1564-20
Size 50 μg
Alternate Name ICAM3, Intercellular adhesion molecule 3, ICAM-3, CD50, CDW50, ICAM-R, intercellular adhesion molecule 3 isoform 1
Gene Symbol ICAM3
Gene ID 3385
Accession # P32942
Source Baculovirus
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 76.7 kDa (hIgG-His-tag at C-terminus)
Purity by SDS-PAGE >95%
Endotoxin Level < 1 EU per 1ug of protein (determined by LAL method)
Biological Activity Measured by the ability of the immobilized protein to support the adhesion of HL-60 human promyelocytic cells. When cells are added to Human ICAM-3/CD50 coated plates, the ED50 range ≤4ug/ml.
Amino Acid Sequence aa 30-485
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ICAM-3/CD50, also known as CD50 (Cluster of Differentiation 50), is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulinlike C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leukocytes and maybe the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signaling molecule. Recombinant human ICAM-3/CD50, fused hIgG-His-tag at C-terminus, was expressed in the insect cell and purified by using conventional chromatography techniques.

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Is the His-tag at the C-terminus cleavable?
No, unfortunately, it is not designed to contain any cleavage site and hence His-tag is not cleavable.