A PI3 Kinase inhibitor
Catalog #: 1661 | abID:

Product Details

Cat # +Size 1661-1
Size 1 mg
Alternate Name 2-[6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
Appearance White to off-white solid
CAS # 371242-69-2
Molecular Formula C₂₂H₁₉N₇O
Molecular Weight 397.43
Purity ≥95% by HPLC
Solubility DMSO
InChi InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)
PubChem CID 9908783
MDL Number MFCD09970845
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110δ (IC₅₀ = 60 nM). Inhibits p110α and p110β only at higher concentrations (>1 µM). IC87114 does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and mTOR even at concentrations up to 100 µM.

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Akitaka Fujita, Inhibition of PI3Kδ Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells, Front Immunol., Mar. 2020; 32218789.
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